Regulation of p53 apoptotic ability by Y-box binding protein YB1

Prof. Antony Braithwaite, Pathology Dept., School of Medicine, Universtity of Otago, Dunedine, Neuseeland

Antony Braithwaite is currently a Professor in the Pathology Dept, Dunedin School of Medicine, University of Otago, New Zealand. He completed his PhD in the area of tumour virology in 1983 at the Australian National University in Canberra. His studies focussed on the molecular basis of cell cycle deregulation by human adenoviruses. He was also a postdoctoral fellow at the ANU for 3 years, after which he spent another 3 years with John Jenkins at the Marie Curie Research Institute in England where he began working on p53. He returned to Canberra in 1988/9 becoming a Senior Research Fellow in 1991 and then moved to Dunedin in 1996 where he became Professor in Pathology. Professor Braithwaite's research is on the molecular basis of cancer largely focussed on the regulation of p53 function.

Nuclear YB1 is a prognostic factor for several human cancers, including the most common ones such as breast and prostate (1). YB1 has many functions in the regulation of gene expression, which can occur both at the transcriptional and translational level (1).

Antony Braithwaite and colleges showed previously that p53 is necessary for YB1 to undergo nuclear translocation where it can function as a transcription factor (2). They also showed previously that inhibition of YB1 causes an induction of p53 dependent apoptosis (3).

The seminar will discuss new data regarding the mechanism of YB1 nuclear translocation and the consequences of this for p53 functioning (4). The importance of this in tumour biology is also discussed.

Relevant publications:

  1. Kohno et al (2003) BioEssays, 25.7, 691
  2. Zhang et al (2003) Oncogene, 22, 2782
  3. Lasham et al (2003) J. Biol. Chem., 278, 35516
  4. Homer et al (2005) Oncogene, in press.