Staff
Prof. Dr. Topf, Maya
Head of Research Department Integrative VirologyCurriculum vitae
Since 2020: Head of Research Department Integrative Virology at the LIV, Part of Hamburg Leibniz Science Campus InterACt, localized at Centre for Structural Systems Biology (CSSB), Hamburg, Professor (W3) University Medical Center Hamburg-Eppendorf (UKE), Germany
Publications
Manalastas-Cantos K, Adoni KR, Pfeifer M, Märtens B, Grünewald K, Thalassinos K, Topf M (2024). Modeling Flexible Protein Structure With AlphaFold2 and Crosslinking Mass Spectrometry. Mol Cell Proteomics. 23/2024; PubMed
Beton JG, Mulvaney T, Cragnolini T, Topf M (2024). Cryo-EM structure and B-factor refinement with ensemble representation. Nat Commun. 15/2024; PubMed
Del Moral-Morales A, Sámano C, Ocampo-Cervantes JA, Topf M, Baumbach J, Hernández J, Torres-Arciga K, González-Barrios R, Soto-Reyes E (2024). Key Proteins for Regeneration in A. mexicanum: Transcriptomic Insights From Aged and Juvenile Limbs. Scientifica (Cairo). 2024/2024; PubMed
Mulvaney T, Kretsch RC, Elliott L, Beton JG, Kryshtafovych A, Rigden DJ, Das R, Topf M (2023). CASP15 cryo-EM protein and RNA targets: Refinement and analysis using experimental maps. Proteins. 91/2023; PubMed
Kryshtafovych A, Schwede T, Topf M, Fidelis K, Moult J (2023). Critical assessment of methods of protein structure prediction (CASP)-Round XV. Proteins. 91/2023; PubMed
Genz LR, Mulvaney T, Nair S, Topf M (2023). PICKLUSTER: a protein-interface clustering and analysis plug-in for UCSF ChimeraX. Bioinformatics. 39/2023; PubMed
Malhotra S, Mulvaney T, Cragnolini T, Sidhu H, Joseph AP, Beton JG, Topf M (2023). RIBFIND2: Identifying rigid bodies in protein and nucleic acid structures. Nucleic Acids Res. 51/2023; PubMed
Alexander LT, Durairaj J, Kryshtafovych A, Abriata LA, Bayo Y, Bhabha G, Breyton C, Caulton SG, Chen J, Degroux S, Ekiert DC, Erlandsen BS, Freddolino PL, Gilzer D, Greening C, Grimes JM, Grinter R, Gurusaran M, Hartmann MD, Hitchman CJ, Keown JR, Kropp A, Kursula P, Lovering AL, Lemaitre B, Lia A, Liu S, Logotheti M, Lu S, Markússon S, Miller MD, Minasov G, Niemann HH, Opazo F, Phillips GN, Davies OR, Rommelaere S, Rosas-Lemus M, Roversi P, Satchell K, Smith N, Wilson MA, Wu KL, Xia X, Xiao H, Zhang W, Zhou ZH, Fidelis K, Topf M, Moult J, Schwede T (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins. 91/2023; PubMed
Marini G, Poland B, Leininger C, Lukoyanova N, Spielbauer D, Barry JK, Altier D, Lum A, Scolaro E, Ortega CP, Yalpani N, Sandahl G, Mabry T, Klever J, Nowatzki T, Zhao JZ, Sethi A, Kassa A, Crane V, Lu AL, Nelson ME, Eswar N, Topf M, Saibil HR (2023). Structural journey of an insecticidal protein against western corn rootworm. Nat Commun. 14/2023; PubMed
Kryshtafovych A, Antczak M, Szachniuk M, Zok T, Kretsch RC, Rangan R, Pham P, Das R, Robin X, Studer G, Durairaj J, Eberhardt J, Sweeney A, Topf M, Schwede T, Fidelis K, Moult J (2023). New prediction categories in CASP15. Proteins. 91/2023; PubMed
Das R, Kretsch RC, Simpkin AJ, Mulvaney T, Pham P, Rangan R, Bu F, Keegan RM, Topf M, Rigden DJ, Miao Z, Westhof E (2023). Assessment of three-dimensional RNA structure prediction in CASP15. bioRxiv. 2023 Oct 03; PubMed
Reid KM, Steel D, Nair S, Bhate S, Biassoni L, Sudhakar S, Heys M, Burke E, Kamsteeg EJ, Genomics England Research Consortium , Hameed B, Zech M, Mencacci NE, Barwick K, Topf M, Kurian MA (2023). Loss-of-Function Variants in DRD1 in Infantile Parkinsonism-Dystonia. Cells. 12/2023; PubMed
Steel DBD, Danti FR, Abunada M, Kamien B, Malhotra S, Topf M, Kaliakatsos M, Valentine J, Nemeth AH, Jayawant S, Reid KM, Mankad K, Sudhakar S, Ben-Pazi H, Barwick K, Kurian MA (2023). Clinical Phenotype in Individuals With Birk-Landau-Perez Syndrome Associated With Biallelic SLC30A9 Pathogenic Variants. Neurology. 100/2023; PubMed
Sweeney A, Mulvaney T, Maiorca M, Topf M (2023). ChemEM: Flexible Docking of Small Molecules in Cryo-EM Structures. J Med Chem. 67/2024; PubMed
Das R, Kretsch RC, Simpkin AJ, Mulvaney T, Pham P, Rangan R, Bu F, Keegan RM, Topf M, Rigden DJ, Miao Z, Westhof E (2023). Assessment of three-dimensional RNA structure prediction in CASP15. Proteins. 91/2023; PubMed
Polubothu S, Bender N, Muthiah S, Zecchin D, Demetriou C, Martin SB, Malhotra S, Travnickova J, Zeng Z, Böhm M, Barbarot S, Cottrell C, Davies O, Baselga E, Burrows NP, Carmignac V, Diaz JS, Fink C, Haenssle HA, Happle R, Harland M, Majerowski J, Vabres P, Vincent M, Newton-Bishop JA, Bishop DT, Siegel D, Patton EE, Topf M, Rajan N, Drolet B, Kinsler VA (2022). PTPN11 Mosaicism Causes a Spectrum of Pigmentary and Vascular Neurocutaneous Disorders and Predisposes to Melanoma. J Invest Dermatol. 143/2023; PubMed
Reid KM, Spaull R, Salian S, Barwick K, Meyer E, Zhen J, Hirata H, Sheipouri D, Benkerroum H, Gorman KM, Papandreou A, Simpson MA, Hirano Y, Farabella I, Topf M, Grozeva D, Carss K, Smith M, Pall H, Lunt P, De Gressi S, Kamsteeg EJ, Haack TB, Carr L, Guerreiro R, Bras J, Maher ER, Scott RH, Vandenberg RJ, Raymond FL, Chong WK, Sudhakar S, Mankad K, Reith ME, Campeau PM, Harvey RJ, Kurian MA (2022). MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Mov Disord. 37/2022; PubMed
Ivanova ME, Lukoyanova N, Malhotra S, Topf M, Trapani JA, Voskoboinik I, Saibil HR (2022). The pore conformation of lymphocyte perforin. Sci Adv. 8/2022; PubMed
Soloviev Z, Bullock JMA, James JMB, Sauerwein AC, Nettleship JE, Owens RJ, Hansen DF, Topf M, Thalassinos K (2022). Structural mass spectrometry decodes domain interaction and dynamics of the full-length Human Histone Deacetylase 2. Biochim Biophys Acta Proteins Proteom. 1870/2022; PubMed
Topf M, Rosta E, Bowman GR, Bonomi M (2021). Editorial: Experiments and Simulations: A Pas de Deux to Unravel Biological Function. Front Mol Biosci. 8/2021; PubMed
Alexander LT, Lepore R, Kryshtafovych A, Adamopoulos A, Alahuhta M, Arvin AM, Bomble YJ, Böttcher B, Breyton C, Chiarini V, Chinnam NB, Chiu W, Fidelis K, Grinter R, Gupta GD, Hartmann MD, Hayes CS, Heidebrecht T, Ilari A, Joachimiak A, Kim Y, Linares R, Lovering AL, Lunin VV, Lupas AN, Makbul C, Michalska K, Moult J, Mukherjee PK, Nutt WS, Oliver SL, Perrakis A, Stols L, Tainer JA, Topf M, Tsutakawa SE, Valdivia-Delgado M, Schwede T (2021). Target highlights in CASP14: Analysis of models by structure providers. Proteins. 89/2021; PubMed
Kryshtafovych A, Schwede T, Topf M, Fidelis K, Moult J (2021). Critical assessment of methods of protein structure prediction (CASP)-Round XIV. Proteins. 89/2021; PubMed
Cragnolini T, Kryshtafovych A, Topf M (2021). Cryo-EM targets in CASP14. Proteins. 89/2021; PubMed
Malhotra S, Joseph AP, Thiyagalingam J, Topf M (2021). Assessment of protein-protein interfaces in cryo-EM derived assemblies. Nat Commun. 12/2021; PubMed
Beton JG, Moorehead R, Helfmann L, Gray R, Hoogenboom BW, Joseph AP, Topf M, Pyne ALB (2021). TopoStats - A program for automated tracing of biomolecules from AFM images. Methods. 193/2021; PubMed
Vollmer B, Pražák V, Vasishtan D, Jefferys EE, Hernandez-Duran A, Vallbracht M, Klupp BG, Mettenleiter TC, Backovic M, Rey FA, Topf M, Grünewald K (2020). The prefusion structure of herpes simplex virus glycoprotein B. Sci Adv. 6/2020; PubMed
Hernández Durán A, Grünewald K, Topf M (2019). Conserved Central Intraviral Protein Interactome of the Herpesviridae Family. mSystems. 4/2019; PubMed
Hernández Durán A, Greco TM, Vollmer B, Cristea IM, Grünewald K, Topf M (2019). Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol. 17/2019; PubMed
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