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von Stromberg K, Seddar L, Gornott B, Dobner T, Bertzbach LD, Ip W-H (2026). The adenovirus oncoprotein E1B-55K reshapes epigenetic histone modifications in primary human cells. mBio. 2026 Jan 26; PubMed

Ip WH, Bertzbach LD, Schreiner S, Dobner T (2025). Adenovirus E1B-55K interferes with cellular IκB kinase complex subunit proteins. Front Immunol. 16/2025; PubMed

Schloer S, Hennesen J, Rueschpler L, Zamzamy M, Flomm F, Ip WH, Pirosu A, Dobner T, Altfeld M (2025). The host cell factor DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon TLR activation. Pharmacol Res. 2025 May 10; PubMed

Schloer S, Hennesen J, Rueschpler L, Zamzamy M, Flomm F, Skenteris NT, Ip WH, Pirosu A, Dobner T, Altfeld M (2025). Corrigendum to "The host cell factor DDX3 mediates sex dimorphism in the IFNα response of plasmacytoid dendritic cells upon TLR activation" [Pharmacol. Res. 216(June) (2025) 107764]. Pharmacol Res. 2025 Aug 01; PubMed

Hidalgo P, Gornott B, Bertzbach LD, Dobner T (2025). Proviral functions of HMGB1 in HAdV-C5 replication compartments. Microbiol Spectr. 2025 Sep 08; PubMed

Seddar L, von Stromberg K, Bertzbach LD, Grundhoff A, Dobner T, Ip WH (2025). Adenovirus E1B-55K regulates p53-dependent and -independent gene expression during infection. PLoS Pathog. 21/2025; PubMed

Zamzamy M, Post S, Ip WH, Hahlin E, Kühn S, Pirosu A, Conze C, Baumdick M, Bunders MJ, Zecher BF, Hoelzemer A, Linder S, Arnberg N, Dobner T, Altfeld M, Schloer S (2025). Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir. Br J Pharmacol. 2025 Nov 28; PubMed

Bertzbach LD, Ip WH, von Stromberg K, Dobner T, Grand RJ (2024). A comparative review of adenovirus A12 and C5 oncogenes. Curr Opin Virol. 67/2024; PubMed

Bertzbach LD, Seddar L, von Stromberg K, Ip W-H, Dobner T, Hidalgo P (2024). The adenovirus DNA-binding protein DBP. J Virol. 98/2024; PubMed

Herrmann A, Gege C, Wangen C, Wagner S, Kögler M, Cordsmeier A, Irrgang P, Ip WH, Weil T, Hunszinger V, Groß R, Heinen N, Pfaender S, Reuter S, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Grunwald T, Hietel B, Cynis H, Münch J, Sparrer KMJ, Ensser A, Tenbusch M, Dobner T, Vitt D, Kohlhof H, Hahn F (2024). Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity. Antiviral Res. 231/2024; PubMed

Ip WH, Fiedler M, Gornott B, Morische M, Bertzbach LD, Dobner T (2024). Cellular SUMO-specific proteases regulate HAdV-C5 E1B-55K SUMOylation and virus-induced cell transformation. Front Cell Infect Microbiol. 14/2024; PubMed

Hidalgo P, Torres A, Jean Beltran PM, López-Leal G, Bertzbach LD, Dobner T, Flint SJ, Cristea IM, González RA (2024). The protein composition of human adenovirus replication compartments. mBio. 16/2025; PubMed

Dobner T, Bertzbach LD (2023). Updates and New Perspectives on Adenoviral Gene Therapy and Vaccine Vectors. Viruses. 15/2023; PubMed

Ip WH, Bertzbach LD, Speiseder T, Dobner T (2023). The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro. Tumour Virus Res. 15/2023; PubMed

Chalabi Hagkarim N, Ip WH, Bertzbach LD, Abualfaraj T, Dobner T, Molloy DP, Stewart GS, Grand RJ (2023). Identification of Adenovirus E1B-55K Interaction Partners through a Common Binding Motif. Viruses. 15/2023; PubMed

Ip W-H, Tatham MH, Krohne S, Gruhne J, Melling M, Meyer T, Gornott B, Bertzbach LD, Hay RT, Rodriguez E, Dobner T (2023). Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors. J Virol. 97/2023; PubMed

von Stromberg K, Seddar L, Ip WH, Günther T, Gornott B, Weinert SC, Hüppner M, Bertzbach LD, Dobner T (2023). The human adenovirus E1B-55K oncoprotein coordinates cell transformation through regulation of DNA-bound host transcription factors. Proc Natl Acad Sci U S A. 120/2023; PubMed

Alemán MV, Bertzbach LD, Speiseder T, Ip WH, González RA, Dobner T (2022). Global Transcriptome Analyses of Cellular and Viral mRNAs during HAdV-C5 Infection Highlight New Aspects of Viral mRNA Biogenesis and Cytoplasmic Viral mRNA Accumulations. Viruses. 14/2022; PubMed

Márquez V, Ballesteros G, Dobner T, González RA (2022). Adipocyte commitment of 3T3-L1 cells is required to support human adenovirus 36 productive replication concurrent with altered lipid and glucose metabolism. Front Cell Infect Microbiol. 12/2022; PubMed

Mai J, Stubbe M, Hofmann S, Masser S, Dobner T, Boutell C, Groitl P, Schreiner S (2022). PML Alternative Splice Products Differentially Regulate HAdV Productive Infection. Microbiol Spectr. 10/2022; PubMed

Fiedler M, Ip WH, Hofmann-Sieber H, Wilkens B, Nkrumah FK, Zhang W, Ehrhardt A, Bertzbach LD, Dobner T (2022). Protein-Protein Interactions Facilitate E4orf6-Dependent Regulation of E1B-55K SUMOylation in HAdV-C5 Infection. Viruses. 14/2022; PubMed

Boddin J, Ip WH, Wilkens B, von Stromberg K, Ching W, Koyuncu E, Bertzbach LD, Dobner T (2022). A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. mBio. 13/2022; PubMed

Hidalgo P, Garcés Y, Mundo E, López RE, Bertzbach LD, Dobner T, González RA (2022). E1B-55K Is a Phosphorylation-Dependent Transcriptional and Posttranscriptional Regulator of Viral Gene Expression in Human Adenovirus C5 Infection. J Virol. 96/2022; PubMed

Bertzbach LD, Ip WH, Dobner T (2021). Animal Models in Human Adenovirus Research. Biology (Basel). 10/2021; PubMed

Pfitzner S, Bosse JB, Hofmann-Sieber H, Flomm F, Reimer R, Dobner T, Grünewald K, Franken LE (2021). Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. Int J Mol Sci. 22/2021; PubMed

Kolbe V, Ip WH, Kieweg-Thompson L, Lang J, Gruhne J, Meyer T, Wilkens B, Schie M, Thünauer R, Schreiner S, Bertzbach LD, Rodríguez E, Dobner T (2021). Conserved E1B-55K SUMOylation in Different Human Adenovirus Species Is a Potent Regulator of Intracellular Localization. J Virol. 96/2022; PubMed

Hidalgo P, Pimentel A, Mojica-Santamaría D, von Stromberg K, Hofmann-Sieber H, Lona-Arrona C, Dobner T, González RA (2021). Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments. Viruses. 13/2021; PubMed

Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M, Belderbos M, Dobner T, Bunders MJ (2021). KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. Sci Immunol. 6/2021; PubMed

Ip WH, Wilkens B, Solomatina A, Martin J, Melling M, Hidalgo P, Bertzbach LD, Speiseder T, Dobner T (2021). Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes. Viruses. 13/2021; PubMed

Pfitzner S, Hofmann-Sieber H, Bosse JB, Franken LE, Grünewald K, Dobner T (2020). Fluorescent protein tagging of adenoviral proteins pV and pIX reveals 'late virion accumulation compartment'. PLoS Pathog. 16/2020; PubMed

Hofmann-Sieber H, Gonzalez G, Spohn M, Dobner T, Kajon AE (2020). Genomic and phylogenetic analysis of two guinea pig adenovirus strains recovered from archival lung tissue. Virus Res. 285/2020; PubMed

Stubbe M, Mai J, Paulus C, Stubbe HC, Berscheminski J, Karimi M, Hofmann S, Weber E, Hadian K, Hay R, Groitl P, Nevels M, Dobner T, Schreiner S (2020). Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers. mBio. 11/2020; PubMed

Czech-Sioli M, Siebels S, Radau S, Zahedi RP, Schmidt C, Dobner T, Grundhoff A, Fischer N (2020). The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication. J Virol. 94/2020; PubMed

Ip WH, Dobner T (2019). Cell transformation by the adenovirus oncogenes E1 and E4. FEBS Lett. 594/2020; PubMed

Hidalgo P, Ip WH, Dobner T, Gonzalez RA (2019). The biology of the adenovirus E1B 55K protein. FEBS Lett. 593/2019; PubMed

Tejera B, López RE, Hidalgo P, Cárdenas R, Ballesteros G, Rivillas L, French L, Amero C, Pastor N, Santiago Á, Groitl P, Dobner T, Gonzalez RA (2019). The human adenovirus type 5 E1B 55kDa protein interacts with RNA promoting timely DNA replication and viral late mRNA metabolism. PLoS One. 14/2019; PubMed

Dhingra A, Hage E, Ganzenmueller T, Böttcher S, Hofmann J, Hamprecht K, Obermeier P, Rath B, Hausmann F, Dobner T, Heim A (2019). Molecular Evolution of Human Adenovirus (HAdV) Species C. Sci Rep. 9/2019; PubMed

Müncheberg S, Hay RT, Ip WH, Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S (2018). E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression. J Virol. 92/2018; PubMed

Chalabi Hagkarim N, Ryan EL, Byrd PJ, Hollingworth R, Shimwell NJ, Agathanggelou A, Vavasseur M, Kolbe V, Speiseder T, Dobner T, Stewart GS, Grand RJ (2018). Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection. J Virol. 92/2018; PubMed

Kosulin K, Lam E, Heim A, Dobner T, Rodríguez E (2018). Broad-spectrum antiviral activity of the deubiquitinase inhibitor HBX against human adenoviruses. Antivir Ther. 23/2018; PubMed

Freudenberger N, Meyer T, Groitl P, Dobner T, Schreiner S (2018). Human Adenovirus Core Protein V Is Targeted by the Host SUMOylation Machinery To Limit Essential Viral Functions. J Virol. 92/2018; PubMed

Rodríguez E, Ip WH, Kolbe V, Hartmann K, Pilnitz-Stolze G, Tekin N, Gómez-Medina S, Muñoz-Fontela C, Krasemann S, Dobner T (2016). Humanized Mice Reproduce Acute and Persistent Human Adenovirus Infection. J Infect Dis. 215/2017; PubMed

Speiseder T, Hofmann-Sieber H, Rodríguez E, Schellenberg A, Akyüz N, Dierlamm J, Spruss T, Lange C, Dobner T (2016). Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes. J Virol. 91/2017; PubMed

Neumann F, Czech-Sioli M, Dobner T, Grundhoff A, Schreiner S, Fischer N (2016). Replication of Merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies. J Gen Virol. 97/2016; PubMed

Hidalgo P, Anzures L, Hernández-Mendoza A, Guerrero A, Wood CD, Valdés M, Dobner T, Gonzalez RA (2016). Morphological, Biochemical, and Functional Study of Viral Replication Compartments Isolated from Adenovirus-Infected Cells. J Virol. 90/2016; PubMed

Nikitenko NA, Speiseder T, Chernolovskaya EL, Zenkova MA, Dobner T, Prassolov VS (2016). [Downregulation of Human Adenovirus DNA Polymerase Gene by Modified siRNAs]. Mol Biol (Mosk). 50/2016; PubMed

Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P (2015). The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity. mSphere. 1/2016; PubMed

Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P (2015). The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F. mSphere. 1/2016; PubMed

Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, Schreiner S (2015). KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification. J Virol. 90/2016; PubMed

Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A (2015). Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1. PLoS One. 10/2015; PubMed

Nikitenko NA, Speiseder T, Groitl P, Spirin PV, Prokofjeva MM, Lebedev TD, Rubtsov PM, Lam E, Riecken K, Fehse B, Dobner T, Prassolov VS (2015). Targeting species D adenoviruses replication to counteract the epidemic keratoconjunctivitis. Biochimie. 113/2015; PubMed

Turner RL, Groitl P, Dobner T, Ornelles DA (2015). Adenovirus replaces mitotic checkpoint controls. J Virol. 89/2015; PubMed

Nikitenko NA, Speiseder T, Lam E, Rubtsov PM, Tonaeva KhD, Borzenok SA, Dobner T, Prassolov VS (2015). Regulation of Human Adenovirus Replication by RNA Interference. Acta Naturae. 7/2015; PubMed

Berscheminski J, Brun J, Speiseder T, Wimmer P, Ip WH, Terzic M, Dobner T, Schreiner S (2015). Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation. Oncogene. 35/2016; PubMed

Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S (2015). PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 35/2016; PubMed

Günther T, Schreiner S, Dobner T, Tessmer U, Grundhoff A (2014). Influence of ND10 components on epigenetic determinants of early KSHV latency establishment. PLoS Pathog. 10/2014; PubMed

Berscheminski J, Wimmer P, Brun J, Ip WH, Groitl P, Horlacher T, Jaffray E, Hay RT, Dobner T, Schreiner S (2014). Sp100 isoform-specific regulation of human adenovirus 5 gene expression. J Virol. 88/2014; PubMed

Speiseder T, Nevels M, Dobner T (2014). Determination of the transforming activities of adenovirus oncogenes. Methods Mol Biol. 1089/2014; PubMed

Schreiner S, Kinkley S, Bürck C, Mund A, Wimmer P, Schubert T, Groitl P, Will H, Dobner T (2013). SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection. PLoS Pathog. 9/2013; PubMed

Schmid M, Speiseder T, Dobner T, Gonzalez RA (2013). DNA virus replication compartments. J Virol. 88/2014; PubMed

Kosulin K, Hoffmann F, Clauditz TS, Wilczak W, Dobner T (2013). Presence of adenovirus species C in infiltrating lymphocytes of human sarcoma. PLoS One. 8/2013; PubMed

Ching W, Koyuncu E, Singh S, Arbelo-Roman C, Hartl B, Kremmer E, Speiseder T, Meier C, Dobner T (2013). A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation. PLoS Pathog. 9/2013; PubMed

Schreiner S, Bürck C, Glass M, Groitl P, Wimmer P, Kinkley S, Mund A, Everett RD, Dobner T (2013). Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes. Nucleic Acids Res. 41/2013; PubMed

Koyuncu OO, Speiseder T, Dobner T, Schmid M (2012). Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis. J Virol. 87/2013; PubMed

Berscheminski J, Groitl P, Dobner T, Wimmer P, Schreiner S (2012). The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription. J Virol. 87/2013; PubMed

Müller D, Schreiner S, Schmid M, Groitl P, Winkler M, Dobner T (2012). Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7. J Virol. 86/2012; PubMed

Schreiner S, Martinez R, Groitl P, Rayne F, Vaillant R, Wimmer P, Bossis G, Sternsdorf T, Marcinowski L, Ruzsics Z, Dobner T, Wodrich H (2012). Transcriptional activation of the adenoviral genome is mediated by capsid protein VI. PLoS Pathog. 8/2012; PubMed

Schreiner S, Wimmer P, Dobner T (2012). Adenovirus degradation of cellular proteins. Future Microbiol. 7/2012; PubMed

Wimmer P, Blanchette P, Schreiner S, Ching W, Groitl P, Berscheminski J, Branton PE, Will H, Dobner T (2012). Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein. Oncogene. 32/2013; PubMed

Ching W, Dobner T, Koyuncu E (2011). The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2. J Virol. 86/2012; PubMed

Schmid M, Gonzalez RA, Dobner T (2011). CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts. J Virol. 86/2012; PubMed

Wimmer P, Schreiner S, Dobner T (2011). Human pathogens and the host cell SUMOylation system. J Virol. 86/2012; PubMed

Sieber T, Scholz R, Spoerner M, Schumann F, Kalbitzer HR, Dobner T (2011). Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R. Virology. 418/2011; PubMed

Schreiner S, Wimmer P, Groitl P, Chen SY, Blanchette P, Branton PE, Dobner T (2011). Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells. J Virol. 85/2011; PubMed

Schmid M, Kindsmüller K, Wimmer P, Groitl P, Gonzalez RA, Dobner T (2011). The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export. J Virol. 85/2011; PubMed

Schreiner S, Wimmer P, Sirma H, Everett RD, Blanchette P, Groitl P, Dobner T (2010). Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells. J Virol. 84/2010; PubMed

Wimmer P, Täuber B, Spruss T, Dobner T (2010). Adenovirus type 5 early encoded proteins of the E1 and E4 regions induce oncogenic transformation of primary rabbit cells. J Gen Virol. 91/2010; PubMed

Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T, Kirchhoff F (2010). Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue. Retrovirology. 7/2010; PubMed

Wimmer P, Schreiner S, Everett RD, Sirma H, Groitl P, Dobner T (2010). SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML. Oncogene. 29/2010; PubMed

Kindsmüller K, Schreiner S, Leinenkugel F, Groitl P, Kremmer E, Dobner T (2009). A 49-kilodalton isoform of the adenovirus type 5 early region 1B 55-kilodalton protein is sufficient to support virus replication. J Virol. 83/2009; PubMed

Koyuncu OO, Dobner T (2009). Arginine methylation of human adenovirus type 5 L4 100-kilodalton protein is required for efficient virus production. J Virol. 83/2009; PubMed

Blanchette P, Kindsmüller K, Groitl P, Dallaire F, Speiseder T, Branton PE, Dobner T (2008). Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity. J Virol. 82/2008; PubMed

Härtl B, Zeller T, Blanchette P, Kremmer E, Dobner T (2008). Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription. Oncogene. 27/2008; PubMed

Kindsmüller K, Groitl P, Härtl B, Blanchette P, Hauber J, Dobner T (2007). Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation. Proc Natl Acad Sci U S A. 104/2007; PubMed