Prof. Marcus Altfeld

Prof. Marcus Altfeld

HPI Research Department head Prof. Marcus Altfeld receives ERC Advanced Grant

Wednesday, 01. April 2020

Hamburg. Prof. Marcus Altfeld, Head of the Research Department "Virus Immunology" at the Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology (HPI), Director of the Institute of Immunology at the University Medical Center Hamburg-Eppendorf (UKE) and Coordinator of the HIV Research Unit at the German Center for Infection Research (DZIF), receives an ERC Advanced Grant from the European Research Council (ERC). This highly endowed grant will be used to investigate the regulation of the function of natural killer cells (NK cells) in greater detail.

The project entitled "RegNK" (Regulation of NK cell function), which is supported by the ERC Advanced Grant, investigates the binding of NK cell receptors to HLA class II molecules and their influence on human diseases, such as hepatitis B virus infections.

For this aim, functional immunological and virological approaches are combined with human organoid systems and proteomics technologies. The knowledge gained in this way should ultimately make it possible to use NK cells for immunotherapeutic interventions against infections and inflammatory diseases.

"If we understand the molecular mechanisms by which NK cells influence the immune response against diseases, new targeted starting points for immunotherapeutic approaches can be developed," said Prof. Marcus Altfeld explaining the project goal.

Prof. Thomas Dobner, Scientific Director at HPI, is also happy about this success: "We are especially proud of the ERC Advanced Grant for a project at the Heinrich Pette Institute, because it clearly shows how excellent the level of our research here at HPI is."

The ERC Advanced Grants are aimed at established, active scientists with an outstanding scientific track record.

Prof. Marcus Altfeld has been Head of the Research Department "Virus Immunology" at the Heinrich-Pette-Institute and Professor of Medicine at the University Medical Center Hamburg-Eppendorf since 2013. Since 2017 he is also director of the Institute of Immunology at the UKE. In 2018 he took over the coordination of the research area HIV at the DZIF.

The "RegNK" project is funded over a period of five years.



Prof. Marcus Altfeld: marcus.altfeld(at)  

Heinrich Pette Institute, Leibniz Institute for Experimental Virology,




Picture© HPI/Gisela Köhler Fotodesign