Scheme of viral capsid intermediate selection in a quadrupole
Methods
- state-of-the-art mass spectrometry (MS) techniques: native, ion mobility, TopDown and BottomUp proteomics, hydrogen/deuterium-exchange, labelling, crosslinking
- classical biochemical and cell biological methods for data verification
- application of X-ray lasers to biological problems
Recent Publications
Kierspel T, Kadek A, Barran P, Bellina B, Bijedic A, Brodmerkel MN, Commandeur J, (..), Uetrecht C; MS SPIDOC Consortium (2023). Coherent diffractive imaging of proteins and viral capsids: simulating MS SPIDOC. Anal Bioanal Chem. 2023 Apr 4.
Brodmerkel MN, De Santis E, Uetrecht C, Caleman C, Marklund EG (2022). Stability and conformational memory of electrosprayed and rehydrated bacteriophage MS2 virus coat proteins. Curr Res Struct Biol. 2022 Nov 4;4:338-348.
Creutznacher R, Maass T, Dülfer J, Feldmann C, Hartmann V, Lane MS, Knickmann J, Westermann LT, Thiede L, Smith TJ, Uetrecht C, Mallagaray A, Waudby CA, Taube S, Peters T (2022). Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions. Commun Biol. 2022 Jun 9;5(1):563.