Methods

  • Computational Structural Biology  
  • Macromolecular Assemblies
  • Viral Protein Interaction Networks
  • Cryo Electron Microscopy
  • Cryo EM Validation
  • Image Processing
  • Density Fitting
  • Integrative Modeling
  • Molecular Simulations
  • Molecular Docking


Recent Publications

Ivanova ME, Lukoyanova N, Malhotra S, Topf M, Trapani JA, Voskoboinik I, Saibil HR (2022). The pore conformation of lymphocyte perforin. Sci Adv. 2022 Feb 11;8(6):eabk3147.

Polubothu S, Bender N, Muthiah S, Zecchin D, Demetriou C, Martin SB, Malhotra S, Travnickova J, Zeng Z, Böhm M, Barbarot S, Cottrell C, Davies O, Baselga E, Burrows NP, Carmignac V, Diaz JS, Fink C, (...), Topf M, Rajan N, Drolet B, Kinsler VA (2022). PTPN11 mosaicism causes a spectrum of pigmentary and vascular neurocutaneous disorders and predisposes to melanoma. J Invest Dermatol. 2022 Dec 22:S0022-202X(22)02891-3.

Reid KM, Spaull R, Salian S, Barwick K, (...), Topf M, Grozeva D, Carss K, (...), Campeau PM, Harvey RJ, Kurian MA (2022). MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Mov Disord. 2022 Jul 25.