Integrative Virology

The Department of Integrative Virology, headed by Prof. Dr. Maya Topf, specializes in integrative modelling methods that help to elucidate the structures of large macromolecular complexes, especially viruses. They analyze protein-protein interaction networks, use AI-based approaches to predict and evaluate structural models and design experiments to test the models.

Topf group 2022Topf group 2022 © Gisela Köhler
ChemEM-Software © Maya TopfThe ChemEM software uses CryoEM data for the docking of ligands to protein binding sites. Paper in the Journal of Medical Chemistry
TEMPy-ReFF Methode © Maya TopfTEMPy-ReFF, a new method for improving atomic structures in cryo-EM density maps. Paper in Nature Communications

The departments research approaches aim to bridge the gap between the molecular and cellular level by better interpreting experimental data. Currently, her research focuses on data from cryo-EM, cryo-ET and mass spectrometry and is applied to herpesviruses and arenaviruses. Another topic is pore-forming proteins from the MACPF family and the development of methods for the docking of small molecules.

Team members

Project and Team Manager
Postdoctoral Fellow
Student
Postdoctoral Fellow (Guest)
Postdoctoral Fellow (Guest)
Postdoctoral Fellow (Guest)
Technician (Guest)
Graduate Student
Research Assistant
Project lead Drug Discovery (Guest)
Graduate Student
Research Assistant
Portrait von Maya Topf
Head of Department