Quantitative and Molecular Virology
The associated research group Quantitative and Molecular Virology, headed by Prof. Dr Jens B. Bosse, focuses on analysing the spatio-temporal orchestration of viral morphogenesis in order to understand how protein interaction networks function in a living cell. The aim is to quantitatively dissect complex host-pathogen interactions in the context of individual living cells
The aim is to integrate virus-host and virus-virus protein-protein interactions with four-dimensional information from living cells to study the specific functions of essential molecular complexes in space and time in their native environment. To this end, they rely heavily on state-of-the-art live cell imaging and image analysis methods that provide real-time volume information from whole infected cells. In addition, they utilise protein structure predictions of complete viral proteomes and protein-protein interaction networks to identify critical interactions that can be studied in living, infected cells. This approach has the potential to identify bottlenecks in viral productivity that can serve as targets for intervention.
Contact
Head of Associated Research Group
Phone: +49 (0)40 8998-87645
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Address
Centre for Structural Systems Biology (CSSB)
Notkestraße 85
22607 Hamburg
Team members
Prof. Dr. Jens Bernhard Bosse
Head of Associated Research GroupContact
Head of Associated Research Group
Phone: +49 (0)40 8998-87645
Email: Please enable JavaScript to render this link!
Address
Centre for Structural Systems Biology (CSSB)
Notkestraße 85
22607 Hamburg