Mitarbeiterinnen und Mitarbeiter

Prof. Dr. Bosse, Jens Bernhard

Leitung Assoziierte Gruppe Quantitative Virologie

+49 (0)40 8998-87645

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Curriculum vitae

Since 2020: Junior Professor (W1) for Quantitative Virology, RESIST Cluster of Excellence Hannover Medical School (MHH) at Centre for Structural Systems Biology (CSSB) & associated at the LIV

2018-2020: Head of Light Microscopy core and Nikon Center of Excellence at the LIV

2016-2020: Head of Research Unit Quantitative Virology at the Department Structural Cell Biology of Viruses at the LIV

2015-2016: DFG Return Fellow at the LIV

2011-2015: Postdoctoral Fellow and DFG Research Fellow, Department of Molecular Biology, Princeton University, USA

2011: Doctorate (Dr. rer. nat.) Max von Pettenkofer Institute, University of Munich (LMU)

Publikationen

Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp BG, Mettenleiter TC, Grange M, Grünewald K (2024). Molecular plasticity of herpesvirus nuclear egress analysed in situ. Nat Microbiol. 9/2024; PubMed

Soh TK, Ognibene S, Sanders S, Schäper R, Kaufer BB, Bosse JB (2024). A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses. Nat Commun. 15/2024; PubMed

Bogdanow B, Gruska I, Mühlberg L, Protze J, Hohensee S, Vetter B, Bosse JB, Lehmann M, Sadeghi M, Wiebusch L, Liu F (2023). Spatially resolved protein map of intact human cytomegalovirus virions. Nat Microbiol. 8/2023; PubMed

Sanders S, Jensen Y, Reimer R, Bosse JB (2023). From the beginnings to multidimensional light and electron microscopy of virus morphogenesis. Adv Virus Res. 116/2023; PubMed

Lewis HC, Kelnhofer-Millevolte LE, Brinkley MR, Arbach HE, Arnold EA, Sanders S, Bosse JB, Ramachandran S, Avgousti DC (2023). HSV-1 exploits host heterochromatin for nuclear egress. J Cell Biol. 222/2023; PubMed

Sterrenberg VT, Stalling D, Knaack JIH, Soh TK, Bosse JB, Meier C (2023). A TriPPPro-Nucleotide Reporter with Optimized Cell-Permeable Dyes for Metabolic Labeling of Cellular and Viral DNA in Living Cells. Angew Chem Int Ed Engl. 62/2023; PubMed

Soh TK, Pfefferle S, Wurr S, von Possel R, Oestereich L, Rieger T, Uetrecht C, Rosenthal M, Bosse JB (2023). A validated protocol to UV-inactivate SARS-CoV-2 and herpesvirus-infected cells. PLoS One. 18/2023; PubMed

Bosse JB, Brune W (2023). Viral dew: Phase separation and the formation of viral replication compartments. PLoS Pathog. 19/2023; PubMed

Caragliano E, Brune W, Bosse JB (2022). Herpesvirus Replication Compartments: Dynamic Biomolecular Condensates? Viruses. 14/2022; PubMed

Wedemann L, Flomm FJ, Bosse JB (2022). The unconventional way out-Egress of HCMV through multiviral bodies. Mol Microbiol. 117/2022; PubMed

Caragliano E, Bonazza S, Frascaroli G, Tang J, Soh TK, Grünewald K, Bosse JB, Brune W (2022). Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication. Cell Rep. 38/2022; PubMed

Flomm FJ, Soh TK, Schneider C, Wedemann L, Britt HM, Thalassinos K, Pfitzner S, Reimer R, Grünewald K, Bosse JB (2022). Intermittent bulk release of human cytomegalovirus. PLoS Pathog. 18/2022; PubMed

Borst EM, Harmening S, Sanders S, Caragliano E, Wagner K, Lenac Roviš T, Jonjić S, Bosse JB, Messerle M (2022). A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly. mBio. 13/2022; PubMed

Aho V, Salminen S, Mattola S, Gupta A, Flomm F, Sodeik B, Bosse JB, Vihinen-Ranta M (2021). Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane. PLoS Pathog. 17/2021; PubMed

Pfitzner S, Bosse JB, Hofmann-Sieber H, Flomm F, Reimer R, Dobner T, Grünewald K, Franken LE (2021). Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. Int J Mol Sci. 22/2021; PubMed

Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M, Belderbos M, Dobner T, Bunders MJ (2021). KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. Sci Immunol. 6/2021; PubMed

Rink MR, Baptista MAP, Flomm FJ, Hennig T, Whisnant AW, Wolf N, Seibel J, Dölken L, Bosse JB (2021). Concatemeric Broccoli reduces mRNA stability and induces aggregates. PLoS One. 16/2021; PubMed

Pearson VR, Bosse JB, Koyuncu OO, Scherer J, Toruno C, Robinson R, Abegglen LM, Schiffman JD, Enquist LW, Rall GF (2021). Identification of African Elephant Polyomavirus in wild elephants and the creation of a vector expressing its viral tumor antigens to transform elephant primary cells. PLoS One. 16/2021; PubMed

Langeneckert AE, Lunemann S, Martrus G, Salzberger W, Hess LU, Ziegler AE, Poch T, Ravichandran G, Matschl U, Bosse JB, Tiegs G, Fischer L, Koch M, Herkel J, Oldhafer KJ, Schramm C, Altfeld M (2019). CCL21-expression and accumulation of CCR7+ NK cells in livers of patients with primary sclerosing cholangitis. Eur J Immunol. 49/2019; PubMed

Wang C, Lunelli M, Zschieschang E, Bosse JB, Thuenauer R, Kolbe M (2019). Role of flagellar hydrogen bonding in Salmonella motility and flagellar polymorphic transition. Mol Microbiol. 112/2019; PubMed

Wyler E, Franke V, Menegatti J, Kocks C, Boltengagen A, Praktiknjo S, Walch-Rückheim B, Bosse J, Rajewsky N, Grässer F, Akalin A, Landthaler M (2019). Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program. Nat Commun. 10/2019; PubMed

Nauth T, Huschka F, Schweizer M, Bosse JB, Diepold A, Failla AV, Steffen A, Stradal TEB, Wolters M, Aepfelbacher M (2018). Visualization of translocons in Yersinia type III protein secretion machines during host cell infection. PLoS Pathog. 14/2018; PubMed

Buch A, Müller O, Ivanova L, Döhner K, Bialy D, Bosse JB, Pohlmann A, Binz A, Hegemann M, Nagel CH, Koltzenburg M, Viejo-Borbolla A, Rosenhahn B, Bauerfeind R, Sodeik B (2017). Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting. PLoS Pathog. 13/2017; PubMed