Mitarbeiterinnen und Mitarbeiter
Prof. Dr. Dobner, Thomas
Abteilungsleiter Virale TransformationCurriculum vitae
Since 2007: Scientific Director of the LIV
Since 2006: Professor (W3) and Head of the Department of Viral Transformation at the LIV
2002: Habilitation, Medical Microbiology, University of Regensburg
1996-2006: Research Group Leader, Institute of Medical Microbiology and Hygiene, University of Regensburg
1993-1995: Postdoctoral researcher, Institute of Medical Microbiology and Hygiene, University of Regensburg
1991-1993: Postdoctoral researcher, Department of Molecular Biology, Princeton University, USA
1990: Doctorate (Dr. rer. nat.) University of Munich (LMU)
Publikationen
Dobner T, Bertzbach LD (2023). Updates and New Perspectives on Adenoviral Gene Therapy and Vaccine Vectors. Viruses. 15/2023; PubMed
Ip WH, Bertzbach LD, Speiseder T, Dobner T (2023). The adenoviral E4orf3/4 is a regulatory polypeptide with cell transforming properties in vitro. Tumour Virus Res. 15/2023; PubMed
Chalabi Hagkarim N, Ip WH, Bertzbach LD, Abualfaraj T, Dobner T, Molloy DP, Stewart GS, Grand RJ (2023). Identification of Adenovirus E1B-55K Interaction Partners through a Common Binding Motif. Viruses. 15/2023; PubMed
Ip W-H, Tatham MH, Krohne S, Gruhne J, Melling M, Meyer T, Gornott B, Bertzbach LD, Hay RT, Rodriguez E, Dobner T (2023). Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors. J Virol. 97/2023; PubMed
von Stromberg K, Seddar L, Ip WH, Günther T, Gornott B, Weinert SC, Hüppner M, Bertzbach LD, Dobner T (2023). The human adenovirus E1B-55K oncoprotein coordinates cell transformation through regulation of DNA-bound host transcription factors. Proc Natl Acad Sci U S A. 120/2023; PubMed
Alemán MV, Bertzbach LD, Speiseder T, Ip WH, González RA, Dobner T (2022). Global Transcriptome Analyses of Cellular and Viral mRNAs during HAdV-C5 Infection Highlight New Aspects of Viral mRNA Biogenesis and Cytoplasmic Viral mRNA Accumulations. Viruses. 14/2022; PubMed
Márquez V, Ballesteros G, Dobner T, González RA (2022). Adipocyte commitment of 3T3-L1 cells is required to support human adenovirus 36 productive replication concurrent with altered lipid and glucose metabolism. Front Cell Infect Microbiol. 12/2022; PubMed
Mai J, Stubbe M, Hofmann S, Masser S, Dobner T, Boutell C, Groitl P, Schreiner S (2022). PML Alternative Splice Products Differentially Regulate HAdV Productive Infection. Microbiol Spectr. 10/2022; PubMed
Fiedler M, Ip WH, Hofmann-Sieber H, Wilkens B, Nkrumah FK, Zhang W, Ehrhardt A, Bertzbach LD, Dobner T (2022). Protein-Protein Interactions Facilitate E4orf6-Dependent Regulation of E1B-55K SUMOylation in HAdV-C5 Infection. Viruses. 14/2022; PubMed
Boddin J, Ip WH, Wilkens B, von Stromberg K, Ching W, Koyuncu E, Bertzbach LD, Dobner T (2022). A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. mBio. 13/2022; PubMed
Hidalgo P, Garcés Y, Mundo E, López RE, Bertzbach LD, Dobner T, González RA (2022). E1B-55K Is a Phosphorylation-Dependent Transcriptional and Posttranscriptional Regulator of Viral Gene Expression in Human Adenovirus C5 Infection. J Virol. 96/2022; PubMed
Bertzbach LD, Ip WH, Dobner T (2021). Animal Models in Human Adenovirus Research. Biology (Basel). 10/2021; PubMed
Pfitzner S, Bosse JB, Hofmann-Sieber H, Flomm F, Reimer R, Dobner T, Grünewald K, Franken LE (2021). Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. Int J Mol Sci. 22/2021; PubMed
Kolbe V, Ip WH, Kieweg-Thompson L, Lang J, Gruhne J, Meyer T, Wilkens B, Schie M, Thünauer R, Schreiner S, Bertzbach LD, Rodríguez E, Dobner T (2021). Conserved E1B-55K SUMOylation in Different Human Adenovirus Species Is a Potent Regulator of Intracellular Localization. J Virol. 96/2022; PubMed
Hidalgo P, Pimentel A, Mojica-Santamaría D, von Stromberg K, Hofmann-Sieber H, Lona-Arrona C, Dobner T, González RA (2021). Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments. Viruses. 13/2021; PubMed
Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M, Belderbos M, Dobner T, Bunders MJ (2021). KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. Sci Immunol. 6/2021; PubMed
Ip WH, Wilkens B, Solomatina A, Martin J, Melling M, Hidalgo P, Bertzbach LD, Speiseder T, Dobner T (2021). Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes. Viruses. 13/2021; PubMed
Pfitzner S, Hofmann-Sieber H, Bosse JB, Franken LE, Grünewald K, Dobner T (2020). Fluorescent protein tagging of adenoviral proteins pV and pIX reveals 'late virion accumulation compartment'. PLoS Pathog. 16/2020; PubMed
Hofmann-Sieber H, Gonzalez G, Spohn M, Dobner T, Kajon AE (2020). Genomic and phylogenetic analysis of two guinea pig adenovirus strains recovered from archival lung tissue. Virus Res. 285/2020; PubMed
Stubbe M, Mai J, Paulus C, Stubbe HC, Berscheminski J, Karimi M, Hofmann S, Weber E, Hadian K, Hay R, Groitl P, Nevels M, Dobner T, Schreiner S (2020). Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers. mBio. 11/2020; PubMed
Czech-Sioli M, Siebels S, Radau S, Zahedi RP, Schmidt C, Dobner T, Grundhoff A, Fischer N (2020). The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication. J Virol. 94/2020; PubMed
Ip WH, Dobner T (2019). Cell transformation by the adenovirus oncogenes E1 and E4. FEBS Lett. 594/2020; PubMed
Hidalgo P, Ip WH, Dobner T, Gonzalez RA (2019). The biology of the adenovirus E1B 55K protein. FEBS Lett. 593/2019; PubMed
Tejera B, López RE, Hidalgo P, Cárdenas R, Ballesteros G, Rivillas L, French L, Amero C, Pastor N, Santiago Á, Groitl P, Dobner T, Gonzalez RA (2019). The human adenovirus type 5 E1B 55kDa protein interacts with RNA promoting timely DNA replication and viral late mRNA metabolism. PLoS One. 14/2019; PubMed
Dhingra A, Hage E, Ganzenmueller T, Böttcher S, Hofmann J, Hamprecht K, Obermeier P, Rath B, Hausmann F, Dobner T, Heim A (2019). Molecular Evolution of Human Adenovirus (HAdV) Species C. Sci Rep. 9/2019; PubMed
Müncheberg S, Hay RT, Ip WH, Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S (2018). E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression. J Virol. 92/2018; PubMed
Chalabi Hagkarim N, Ryan EL, Byrd PJ, Hollingworth R, Shimwell NJ, Agathanggelou A, Vavasseur M, Kolbe V, Speiseder T, Dobner T, Stewart GS, Grand RJ (2018). Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection. J Virol. 92/2018; PubMed
Kosulin K, Lam E, Heim A, Dobner T, Rodríguez E (2018). Broad-spectrum antiviral activity of the deubiquitinase inhibitor HBX against human adenoviruses. Antivir Ther. 23/2018; PubMed
Freudenberger N, Meyer T, Groitl P, Dobner T, Schreiner S (2018). Human Adenovirus Core Protein V Is Targeted by the Host SUMOylation Machinery To Limit Essential Viral Functions. J Virol. 92/2018; PubMed
Rodríguez E, Ip WH, Kolbe V, Hartmann K, Pilnitz-Stolze G, Tekin N, Gómez-Medina S, Muñoz-Fontela C, Krasemann S, Dobner T (2016). Humanized Mice Reproduce Acute and Persistent Human Adenovirus Infection. J Infect Dis. 215/2017; PubMed
Speiseder T, Hofmann-Sieber H, Rodríguez E, Schellenberg A, Akyüz N, Dierlamm J, Spruss T, Lange C, Dobner T (2016). Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes. J Virol. 91/2017; PubMed
Neumann F, Czech-Sioli M, Dobner T, Grundhoff A, Schreiner S, Fischer N (2016). Replication of Merkel cell polyomavirus induces reorganization of promyelocytic leukemia nuclear bodies. J Gen Virol. 97/2016; PubMed
Hidalgo P, Anzures L, Hernández-Mendoza A, Guerrero A, Wood CD, Valdés M, Dobner T, Gonzalez RA (2016). Morphological, Biochemical, and Functional Study of Viral Replication Compartments Isolated from Adenovirus-Infected Cells. J Virol. 90/2016; PubMed
Nikitenko NA, Speiseder T, Chernolovskaya EL, Zenkova MA, Dobner T, Prassolov VS (2016). [Downregulation of Human Adenovirus DNA Polymerase Gene by Modified siRNAs]. Mol Biol (Mosk). 50/2016; PubMed
Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P (2015). The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Enhances E1A Functional Activity. mSphere. 1/2016; PubMed
Dallaire F, Schreiner S, Blair GE, Dobner T, Branton PE, Blanchette P (2015). The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F. mSphere. 1/2016; PubMed
Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, Schreiner S (2015). KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification. J Virol. 90/2016; PubMed
Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A (2015). Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1. PLoS One. 10/2015; PubMed
Nikitenko NA, Speiseder T, Groitl P, Spirin PV, Prokofjeva MM, Lebedev TD, Rubtsov PM, Lam E, Riecken K, Fehse B, Dobner T, Prassolov VS (2015). Targeting species D adenoviruses replication to counteract the epidemic keratoconjunctivitis. Biochimie. 113/2015; PubMed
Turner RL, Groitl P, Dobner T, Ornelles DA (2015). Adenovirus replaces mitotic checkpoint controls. J Virol. 89/2015; PubMed
Nikitenko NA, Speiseder T, Lam E, Rubtsov PM, Tonaeva KhD, Borzenok SA, Dobner T, Prassolov VS (2015). Regulation of Human Adenovirus Replication by RNA Interference. Acta Naturae. 7/2015; PubMed
Berscheminski J, Brun J, Speiseder T, Wimmer P, Ip WH, Terzic M, Dobner T, Schreiner S (2015). Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation. Oncogene. 35/2016; PubMed
Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton PE, Hay RT, Dobner T, Schreiner S (2015). PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 35/2016; PubMed
Günther T, Schreiner S, Dobner T, Tessmer U, Grundhoff A (2014). Influence of ND10 components on epigenetic determinants of early KSHV latency establishment. PLoS Pathog. 10/2014; PubMed
Berscheminski J, Wimmer P, Brun J, Ip WH, Groitl P, Horlacher T, Jaffray E, Hay RT, Dobner T, Schreiner S (2014). Sp100 isoform-specific regulation of human adenovirus 5 gene expression. J Virol. 88/2014; PubMed
Speiseder T, Nevels M, Dobner T (2014). Determination of the transforming activities of adenovirus oncogenes. Methods Mol Biol. 1089/2014; PubMed
Schreiner S, Kinkley S, Bürck C, Mund A, Wimmer P, Schubert T, Groitl P, Will H, Dobner T (2013). SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection. PLoS Pathog. 9/2013; PubMed
Schmid M, Speiseder T, Dobner T, Gonzalez RA (2013). DNA virus replication compartments. J Virol. 88/2014; PubMed
Kosulin K, Hoffmann F, Clauditz TS, Wilczak W, Dobner T (2013). Presence of adenovirus species C in infiltrating lymphocytes of human sarcoma. PLoS One. 8/2013; PubMed
Ching W, Koyuncu E, Singh S, Arbelo-Roman C, Hartl B, Kremmer E, Speiseder T, Meier C, Dobner T (2013). A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation. PLoS Pathog. 9/2013; PubMed
Schreiner S, Bürck C, Glass M, Groitl P, Wimmer P, Kinkley S, Mund A, Everett RD, Dobner T (2013). Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes. Nucleic Acids Res. 41/2013; PubMed
Koyuncu OO, Speiseder T, Dobner T, Schmid M (2012). Amino acid exchanges in the putative nuclear export signal of adenovirus type 5 L4-100K severely reduce viral progeny due to effects on hexon biogenesis. J Virol. 87/2013; PubMed
Berscheminski J, Groitl P, Dobner T, Wimmer P, Schreiner S (2012). The adenoviral oncogene E1A-13S interacts with a specific isoform of the tumor suppressor PML to enhance viral transcription. J Virol. 87/2013; PubMed
Müller D, Schreiner S, Schmid M, Groitl P, Winkler M, Dobner T (2012). Functional cooperation between human adenovirus type 5 early region 4, open reading frame 6 protein, and cellular homeobox protein HoxB7. J Virol. 86/2012; PubMed
Schreiner S, Martinez R, Groitl P, Rayne F, Vaillant R, Wimmer P, Bossis G, Sternsdorf T, Marcinowski L, Ruzsics Z, Dobner T, Wodrich H (2012). Transcriptional activation of the adenoviral genome is mediated by capsid protein VI. PLoS Pathog. 8/2012; PubMed
Schreiner S, Wimmer P, Dobner T (2012). Adenovirus degradation of cellular proteins. Future Microbiol. 7/2012; PubMed
Wimmer P, Blanchette P, Schreiner S, Ching W, Groitl P, Berscheminski J, Branton PE, Will H, Dobner T (2012). Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein. Oncogene. 32/2013; PubMed
Ching W, Dobner T, Koyuncu E (2011). The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2. J Virol. 86/2012; PubMed
Schmid M, Gonzalez RA, Dobner T (2011). CRM1-dependent transport supports cytoplasmic accumulation of adenoviral early transcripts. J Virol. 86/2012; PubMed
Wimmer P, Schreiner S, Dobner T (2011). Human pathogens and the host cell SUMOylation system. J Virol. 86/2012; PubMed
Sieber T, Scholz R, Spoerner M, Schumann F, Kalbitzer HR, Dobner T (2011). Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R. Virology. 418/2011; PubMed
Schreiner S, Wimmer P, Groitl P, Chen SY, Blanchette P, Branton PE, Dobner T (2011). Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells. J Virol. 85/2011; PubMed
Schmid M, Kindsmüller K, Wimmer P, Groitl P, Gonzalez RA, Dobner T (2011). The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export. J Virol. 85/2011; PubMed
Schreiner S, Wimmer P, Sirma H, Everett RD, Blanchette P, Groitl P, Dobner T (2010). Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells. J Virol. 84/2010; PubMed
Wimmer P, Täuber B, Spruss T, Dobner T (2010). Adenovirus type 5 early encoded proteins of the E1 and E4 regions induce oncogenic transformation of primary rabbit cells. J Gen Virol. 91/2010; PubMed
Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T, Kirchhoff F (2010). Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue. Retrovirology. 7/2010; PubMed
Wimmer P, Schreiner S, Everett RD, Sirma H, Groitl P, Dobner T (2010). SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML. Oncogene. 29/2010; PubMed
Kindsmüller K, Schreiner S, Leinenkugel F, Groitl P, Kremmer E, Dobner T (2009). A 49-kilodalton isoform of the adenovirus type 5 early region 1B 55-kilodalton protein is sufficient to support virus replication. J Virol. 83/2009; PubMed
Koyuncu OO, Dobner T (2009). Arginine methylation of human adenovirus type 5 L4 100-kilodalton protein is required for efficient virus production. J Virol. 83/2009; PubMed
Blanchette P, Kindsmüller K, Groitl P, Dallaire F, Speiseder T, Branton PE, Dobner T (2008). Control of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activity. J Virol. 82/2008; PubMed
Härtl B, Zeller T, Blanchette P, Kremmer E, Dobner T (2008). Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription. Oncogene. 27/2008; PubMed
Kindsmüller K, Groitl P, Härtl B, Blanchette P, Hauber J, Dobner T (2007). Intranuclear targeting and nuclear export of the adenovirus E1B-55K protein are regulated by SUMO1 conjugation. Proc Natl Acad Sci U S A. 104/2007; PubMed
