Mitarbeiterinnen und Mitarbeiter
PD Dr. Dr. Lange, Ulrike
Nachwuchsgruppenleiterin Genomik Retroviraler InfektionenLebenslauf
Seit 2022: Head of BMFTR Junior Research Group Genomics of Retroviral Infection at the LIV, Hamburg, Deutschland
2015-2022: Clinical Scientist, Department Antiviral Strategies at LIV, Hamburg, Germany
2017-2022: Anaesthesiologist, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Deutschland
2012: Doctorate in Medicine, Max Planck Institute of Immunobiology and Epigenetics, University of Freiburg, Freiburg, Germany
2011-2017: Residency in Anaesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Deutschland
2010: Medical Doctor (MD), University of Freiburg, Freiburg, Germany
2007: PhD in Developmental Biology, Gurdon Institute, University of Cambridge, Cambridge, United Kingdom
2003: MPhil developmental Biology, University of Cambridge, Cambridge,United Kingdom
2001: BSc Anatomy with Basic Medical Sciences, University College London, London, United Kingdom
Publikationen
Ma T, George AF, Li Z, Thomas R, Yin K, Shin MG, Montano M, Matsui Y, Ashokkumar M, Young K, Prigann J, Frouard J, Leddy S, Adiba M, Herrde C, Lange UC, Feschotte C, Nixon DF, Browne EP, Archin NM, Li JZ, Smith D, Deeks S, Søgaard OS, Tolstrup M, Lee S, Pillai SK, Abdel-Mohsen M, Pollard KS, Siliciano R, Ott M, Greene WC, Roan NR (2026). Multiomic analysis of ART-interruption cohorts identifies cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound. Immunity. 2026 Mar 20; PubMed
Reinsberg, F., Schiering, K., Lingstaedt, M. G., Mensching, L., Adiba, M., Kraus, T. V., Engler, J. B., Liebold, I., Bosurgi, L., Schloer, S., Altfeld, M., Friese, M. A., Krasemann, S., Lange, U. C., Garcia-Beltran, W. F. & Hoelzemer, A. (2026). HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microglia bioRxiv. URI
Jahnz, H., Hamann, M. V., Kim, H., Sun, Y., Quiroz, N. S., Zhu, L., Swaiba, U. E., Foth, D., Beschorner, N., Kumar, P. & Lange, U. C. (2026). Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy bioRxiv. URI
Hamann, M. V., Brauckmann, L., Schwarz, C., Spohn, M., Stoeck, R., Leddy, S. M., Frouard, J., Adiba, M., Winzer, R., Virdi, S., Grundhoff, A., Feschotte, C., Muecksch, F., Roan, N. R., Tolosa, E. & Lange, U. C. (2026). Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses bioRxiv. URI
Jahnz H, Hamann MV, Kim H, Sun Y, Salazar-Quiroz N, Zhu L, Leddy SM, Swaiba UE, Schneider C, Foth D, Beschorner N, Kumar P, Lange UC (2026). Development of a Recombinant Adeno-Associated Virus Vector for Human T Lymphocyte- and Natural Killer Cell-Targeted Gene Therapy. Hum Gene Ther. 2026 Sep 16; PubMed
Santangelo M, Bendoumou M, Dutilleul A, Khalfi S, Plant E, Ngassaki-Yoka CD, Pilosio L, Vanhulle C, Dias J, Marray T, Fattaccioli A, Verhasselt B, Lange U, Dieu M, Routy JP, Rohr O, Renard P, Ancuta P, VAN Lint C (2026). Identification of the cellular factor KLF16 as a novel epigenetic repressor of HIV-1 transcription. Res Sq. 2026 Jun 04; PubMed
Hamann MV, Godbole S, Adiba M, Leddy SM, Navolić J, Tabatabai G, Merk DJ, Lange UC, Neumann JE (2025). Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes. Acta Neuropathol Commun. 13/2025; PubMed
Hamann MV, Godbole S, Adiba M, Leddy SM, Navolić J, Tabatabai G, Merk DJ, Lange UC, Neumann JE (2025). Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes. bioRxiv. 2025 May 14; PubMed
Hoelzemer, A., Trenkner, T., Brias, S., Kraus, T., Adiba, M., Nolan, K., Beiersdorfer, M., Vollmers, S., Schäfer, G., Stecher, M., Sauer, G., Behrens, G., Lehmann, C., Meurer, A., Pauli, R., Postel, N., Marseres, G., Sauter, J., Schmidt, A., Roider, J., Scholten, S., Voit, F., Stephan, C., Wolf, E., Schloer, S., Wuen, C., Degen, O., Addo, M., Lohse, A., Schulze zur Wiesch, J., Altfeld, M., Tolosa, E., Adams, E., Lange, U., Gacrica-Beltran W. (2025). HLA-F expression on CD4 T cells in HIV-1 is linked to the presence of viremia and modulated by KIR3DS1 Research Square; URI
Hamann MV, Adiba M, Lange UC (2023). Confounding factors in profiling of locus-specific human endogenous retrovirus (HERV) transcript signatures in primary T cells using multi-study-derived datasets. BMC Med Genomics. 16/2023; PubMed
Lyons DE, Kumar P, Roan NR, Defechereux PA, Feschotte C, Lange UC, Murthy N, Sameshima P, Verdin E, Ake JA, Parsons MS, Nath A, Gianella S, Smith DM, Kallas EG, Villa TJ, Strange R, Mwesigwa B, Furler O'Brien RL, Nixon DF, Ndhlovu LC, Valente ST, Ott M (2023). HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses. 15/2023; PubMed
Hamann MV, Beschorner N, Vu XK, Hauber I, Lange UC, Traenkle B, Kaiser PD, Foth D, Schneider C, Büning H, Rothbauer U, Hauber J (2021). Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors. PLoS One. 16/2021; PubMed
Hamann MV, Ehmele P, Verdikt R, Bialek-Waldmann JK, Virdi S, Günther T, Van Lint C, Grundhoff A, Hauber J, Lange UC (2020). Transcriptional behavior of the HIV-1 promoter in context of the BACH2 prominent proviral integration gene. Virus Res. 293/2021; PubMed
Lange UC, Verdikt R, Ait-Ammar A, Van Lint C (2020). Epigenetic crosstalk in chronic infection with HIV-1. Semin Immunopathol. 42/2020; PubMed
Lange UC, Bialek JK, Walther T, Hauber J (2018). Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection. Virus Res. 249/2018; PubMed
Bialek JK, Walther T, Hauber J, Lange UC (2018). CRISPR-Cas9-based Genome Engineering to Generate Jurkat Reporter Models for HIV-1 Infection with Selected Proviral Integration Sites. J Vis Exp. 2018 Nov 14; PubMed
Karpinski J, Hauber I, Chemnitz J, Schäfer C, Paszkowski-Rogacz M, Chakraborty D, Beschorner N, Hofmann-Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi-Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F (2016). Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nat Biotechnol. 34/2016; PubMed
Bialek JK, Dunay GA, Voges M, Schäfer C, Spohn M, Stucka R, Hauber J, Lange UC (2016). Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems. PLoS One. 11/2016; PubMed
