Mitarbeiterinnen und Mitarbeiter

Marschner J, Marwitz S, Eggers L, von Borstel L, Buer L, Hertz D, Goldmann T, Ostermann E, Brune W, Schneider BE (2026). The impact of cytomegalovirus coinfection on tuberculosis in the mouse model. BMC Infect Dis. 2026 Mar 04; PubMed

Brito LF, Ostermann E, Tödter S, Virdi S, Indenbirken D, Brixel R, Arens R, Grundhoff A, Brune W, Stahl FR (2026). Limited protection against early-life lung murine cytomegalovirus infection results from deficiency of cytotoxic CD8 T cells. PLoS Pathog. 22/2026; PubMed

Klatt V, Meyer Zu Natrup C, Staliunaite L, Clever S, Knickmann J, Ohrnberger S, Seib J, Ostermann E, Weichel HM, Addo MM, Volz A, Brune W (2026). Molecular cloning of a monkeypox virus clade IIb genome and construction of an attenuated mutant for basic and translational research. Emerg Microbes Infect. 15/2026; PubMed

Staliunaite L, Puhach O, Ostermann E, Rosenke K, Nichols J, Oestereich L, Sogoba N, Feldmann H, Davison AJ, Jarvis MA, Brune W (2025). Molecular cloning and host range analysis of three cytomegaloviruses from Mastomys natalensis. J Virol. 2025 Apr 09; PubMed

Luoto L-M, Caragliano E, Schneider C, Reimer R, Brune W (2025). Kaposi's sarcoma-associated herpesvirus ORF61 protein sequesters APOBEC3B in filamentous aggregates. J Virol. 2025 Jun 05; PubMed

Zhou X, Yang L, Cimato G, Frascaroli G, Águeda-Pinto A, Hertel L, Brune W (2025). Increased infectivity of human cytomegalovirus strain TB40/E conferred by variants of the envelope glycoprotein UL128 and the regulatory protein IE2. J Virol. 2025 Aug 11; PubMed

Fonseca Brito L, Ostermann E, Kottlau J, Tödter S, Brixel R, Schüle R, Solano ME, Brune W, Stahl FR (2025). Neuropilin-1 expression modulates infection susceptibility to murine cytomegalovirus at the materno-fetal interface. J Virol. 2025 Nov 25; PubMed

Deng Y, Ostermann E, Brune W (2024). A cytomegalovirus inflammasome inhibitor reduces proinflammatory cytokine release and pyroptosis. Nat Commun. 15/2024; PubMed

Knickmann J, Staliunaite L, Puhach O, Ostermann E, Günther T, Nichols J, Jarvis MA, Voigt S, Grundhoff A, Davison AJ, Brune W (2024). A simple method for rapid cloning of complete herpesvirus genomes. Cell Rep Methods. 4/2024; PubMed

Cimato G, Zhou X, Brune W, Frascaroli G (2024). Human cytomegalovirus glycoprotein variants governing viral tropism and syncytium formation in epithelial cells and macrophages. J Virol. 98/2024; PubMed

Ebert S, Böhm V, Büttner JK, Brune W, Brinkmann MM, Holtappels R, Reddehase MJ, Lemmermann NAW (2024). Cytomegalovirus inhibitors of programmed cell death restrict antigen cross-presentation in the priming of antiviral CD8 T cells. PLoS Pathog. 20/2024; PubMed

Deng Y, Águeda-Pinto A, Brune W (2024). No Time to Die: How Cytomegaloviruses Suppress Apoptosis, Necroptosis, and Pyroptosis. Viruses. 16/2024; PubMed

Ostermann E, Luoto L-M, Clausen M, Virdi S, Brune W (2024). E2F3-dependent activation of FAM111B restricts mouse cytomegalovirus replication in primate cells. J Virol. 98/2024; PubMed

Hansen F, Vučak M, Nichols J, Hughes J, Bane S, Camiolo S, da Silva Filipe A, Ostermann E, Staliunaite L, Chan B, Mauch T, Sogoba N, Streblow DN, Voigt S, Oestereich L, Ehlers B, Redwood AJ, Feldmann H, Brune W, Rosenke K, Jarvis MA, Davison AJ (2023). Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis). J Gen Virol. 104/2023; PubMed

Zhou X, Cimato G, Zhou Y, Frascaroli G, Brune W (2023). A Virus Genetic System to Analyze the Fusogenicity of Human Cytomegalovirus Glycoprotein B Variants. Viruses. 15/2023; PubMed

Bosse JB, Brune W (2023). Viral dew: Phase separation and the formation of viral replication compartments. PLoS Pathog. 19/2023; PubMed

Zhang T, Potgieter TI, Kosche E, Rückert J, Ostermann E, Schulz T, Empting M, Brune W (2023). Thioxothiazolo[3,4-a]quinazoline derivatives inhibit the human cytomegalovirus alkaline nuclease. Antiviral Res. 217/2023; PubMed

Brinkmann NM, Hoffmann C, Wurr S, Pallasch E, Hinzmann J, Ostermann E, Brune W, Eskes ME, Jungblut L, Günther S, Unrau L, Oestereich L (2022). Understanding Host-Virus Interactions: Assessment of Innate Immune Responses in Mastomys natalensis Cells after Arenavirus Infection. Viruses. 14/2022; PubMed

Brizić I, Lisnić B, Krstanović F, Brune W, Hengel H, Jonjić S (2022). Mouse Models for Cytomegalovirus Infections in Newborns and Adults. Curr Protoc. 2/2022; PubMed

Caragliano E, Brune W, Bosse JB (2022). Herpesvirus Replication Compartments: Dynamic Biomolecular Condensates? Viruses. 14/2022; PubMed

Caragliano E, Bonazza S, Frascaroli G, Tang J, Soh TK, Grünewald K, Bosse JB, Brune W (2022). Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication. Cell Rep. 38/2022; PubMed

Muscolino E, Castiglioni C, Brixel R, Frascaroli G, Brune W (2021). Species-Specific Inhibition of Necroptosis by HCMV UL36. Viruses. 13/2021; PubMed

Tang J, Frascaroli G, Zhou X, Knickmann J, Brune W (2021). Cell Fusion and Syncytium Formation in Betaherpesvirus Infection. Viruses. 13/2021; PubMed

Muscolino E, Luoto LM, Brune W (2021). Viral Induced Protein Aggregation: A Mechanism of Immune Evasion. Int J Mol Sci. 22/2021; PubMed

Tallarek AC, Urbschat C, Fonseca Brito L, Stanelle-Bertram S, Krasemann S, Frascaroli G, Thiele K, Wieczorek A, Felber N, Lütgehetmann M, Markert UR, Hecher K, Brune W, Stahl F, Gabriel G, Diemert A, Arck PC (2021). Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy. Front Immunol. 12/2021; PubMed

Hinte F, Müller J, Brune W (2021). Viral mediated tethering to SEL1L facilitates ER-associated degradation of IRE1. J Virol. 95/2021; PubMed

Puhach O, Ostermann E, Krisp C, Frascaroli G, Schlüter H, Brinkmann MM, Brune W (2020). Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication. PLoS Pathog. 16/2020; PubMed

Bogdanow B, Schmidt M, Weisbach H, Gruska I, Vetter B, Imami K, Ostermann E, Brune W, Selbach M, Hagemeier C, Wiebusch L (2020). Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis. Nat Commun. 11/2020; PubMed

Frascaroli G, Rossini G, Maltoni V, Bartoletti M, Ortolani P, Gredmark-Russ S, Gelsomino F, Moroni A, Silenzi S, Castellani G, Sambri V, Mastroianni A, Brune W, Varani S (2020). Genetic and Functional Characterization of Toll-Like Receptor Responses in Immunocompetent Patients With CMV Mononucleosis. Front Cell Infect Microbiol. 10/2020; PubMed

Thiele S, Stanelle-Bertram S, Beck S, Kouassi NM, Zickler M, Müller M, Tuku B, Resa-Infante P, van Riel D, Alawi M, Günther T, Rother F, Hügel S, Reimering S, McHardy A, Grundhoff A, Brune W, Osterhaus A, Bader M, Hartmann E, Gabriel G (2020). Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection. Cell Rep. 31/2020; PubMed

Hinte F, van Anken E, Tirosh B, Brune W (2020). Repression of viral gene expression and replication by the unfolded protein response effector XBP1u. Elife. 9/2020; PubMed

Muscolino E, Schmitz R, Loroch S, Caragliano E, Schneider C, Rizzato M, Kim YH, Krause E, Juranić Lisnić V, Sickmann A, Reimer R, Ostermann E, Brune W (2019). Herpesviruses induce aggregation and selective autophagy of host signalling proteins NEMO and RIPK1 as an immune-evasion mechanism. Nat Microbiol. 5/2020; PubMed

Tang J, Frascaroli G, Lebbink RJ, Ostermann E, Brune W (2019). Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability. Proc Natl Acad Sci U S A. 116/2019; PubMed

Fonseca Brito L, Brune W, Stahl FR (2019). Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity. Int J Mol Sci. 20/2019; PubMed

Koch S, Damas M, Freise A, Hage E, Dhingra A, Rückert J, Gallo A, Kremmer E, Tegge W, Brönstrup M, Brune W, Schulz TF (2019). Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression. PLoS Pathog. 15/2019; PubMed

Tang J, Brixel R, Brune W (2019). Copy-Paste Mutagenesis: A Method for Large-Scale Alteration of Viral Genomes. Int J Mol Sci. 20/2019; PubMed

Ostermann E, Loroch S, Qian Z, Sickmann A, Wiebusch L, Brune W (2018). Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range. PLoS Pathog. 14/2018; PubMed

Stahl FR, Jung R, Jazbutyte V, Ostermann E, Tödter S, Brixel R, Kemmer A, Halle S, Rose-John S, Messerle M, Arck PC, Brune W, Renné T (2018). Laboratory diagnostics of murine blood for detection of mouse cytomegalovirus (MCMV)-induced hepatitis. Sci Rep. 8/2018; PubMed

Brizić I, Lisnić B, Brune W, Hengel H, Jonjić S (2018). Cytomegalovirus Infection: Mouse Model. Curr Protoc Immunol. 122/2018; PubMed

Frascaroli G, Lecher C, Varani S, Setz C, van der Merwe J, Brune W, Mertens T (2018). Human Macrophages Escape Inhibition of Major Histocompatibility Complex-Dependent Antigen Presentation by Cytomegalovirus and Drive Proliferation and Activation of Memory CD4+ and CD8+ T Cells. Front Immunol. 9/2018; PubMed

Bussey KA, Lau U, Schumann S, Gallo A, Osbelt L, Stempel M, Arnold C, Wissing J, Gad HH, Hartmann R, Brune W, Jänsch L, Whitehouse A, Brinkmann MM (2018). The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. PLoS Pathog. 14/2018; PubMed

Brune W, Andoniou CE (2017). Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus. Viruses. 9/2017; PubMed

Schommartz T, Tang J, Brost R, Brune W (2017). Differential Requirement of Human Cytomegalovirus UL112-113 Protein Isoforms for Viral Replication. J Virol. 91/2017; PubMed

Gallo A, Lampe M, Günther T, Brune W (2017). The Viral Bcl-2 Homologs of Kaposi's Sarcoma-Associated Herpesvirus and Rhesus Rhadinovirus Share an Essential Role for Viral Replication. J Virol. 91/2017; PubMed

Ostermann E, Spohn M, Indenbirken D, Brune W (2016). Complete Genome Sequence of a Human Cytomegalovirus Strain AD169 Bacterial Artificial Chromosome Clone. Genome Announc. 4/2016; PubMed

Schommartz T, Loroch S, Alawi M, Grundhoff A, Sickmann A, Brune W (2016). Functional Dissection of an Alternatively Spliced Herpesvirus Gene by Splice Site Mutagenesis. J Virol. 90/2016; PubMed

Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui LR, Brune W, Geballe AP, Beau I, Esclatine A (2016). Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins. Autophagy. 12/2016; PubMed

Hüttmann J, Krause E, Schommartz T, Brune W (2015). Functional Comparison of Molluscum Contagiosum Virus vFLIP MC159 with Murine Cytomegalovirus M36/vICA and M45/vIRA Proteins. J Virol. 90/2015; PubMed

Ostermann E, Warnecke G, Waibler Z, Brune W (2015). Knockout of the Host Resistance Gene Pkr Fully Restores Replication of Murine Cytomegalovirus m142 and m143 Mutants In Vivo. J Virol. 90/2016; PubMed

Mader J, Gallo A, Schommartz T, Handke W, Nagel CH, Günther P, Brune W, Reich K (2015). Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis. J Allergy Clin Immunol. 137/2016; PubMed

Kropp KA, Hsieh WY, Isern E, Forster T, Krause E, Brune W, Angulo A, Ghazal P (2015). A temporal gate for viral enhancers to co-opt Toll-like-receptor transcriptional activation pathways upon acute infection. PLoS Pathog. 11/2015; PubMed

Ostermann E, Pawletko K, Indenbirken D, Schumacher U, Brune W (2015). Stepwise adaptation of murine cytomegalovirus to cells of a foreign host for identification of host range determinants. Med Microbiol Immunol. 204/2015; PubMed

Loroch S, Schommartz T, Brune W, Zahedi RP, Sickmann A (2015). Multidimensional electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) for quantitative analysis of the proteome and phosphoproteome in clinical and biomedical research. Biochim Biophys Acta. 1854/2015; PubMed

Drori A, Messerle M, Brune W, Tirosh B (2014). Lack of XBP-1 impedes murine cytomegalovirus gene expression. PLoS One. 9/2014; PubMed

Krause E, de Graaf M, Fliss PM, Dölken L, Brune W (2014). Murine cytomegalovirus virion-associated protein M45 mediates rapid NF-κB activation after infection. J Virol. 88/2014; PubMed

Bussey KA, Reimer E, Todt H, Denker B, Gallo A, Konrad A, Ottinger M, Adler H, Stürzl M, Brune W, Brinkmann MM (2014). The gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response. J Virol. 88/2014; PubMed

Embarek Mohamed MS, Reiche J, Jacobsen S, Thabit AG, Badary MS, Brune W, Schweiger B, Osmann AH (2014). Molecular analysis of human metapneumovirus detected in patients with lower respiratory tract infection in upper egypt. Int J Microbiol. 2014/2014; PubMed

Stahl S, Burkhart JM, Hinte F, Tirosh B, Mohr H, Zahedi RP, Sickmann A, Ruzsics Z, Budt M, Brune W (2013). Cytomegalovirus downregulates IRE1 to repress the unfolded protein response. PLoS Pathog. 9/2013; PubMed

Handke W, Luig C, Popovic B, Krmpotic A, Jonjic S, Brune W (2013). Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands. J Virol. 87/2013; PubMed

Fliss PM, Brune W (2012). Prevention of cellular suicide by cytomegaloviruses. Viruses. 4/2012; PubMed

Handke W, Krause E, Brune W (2012). Live or let die: manipulation of cellular suicide programs by murine cytomegalovirus. Med Microbiol Immunol. 201/2012; PubMed

Fliss PM, Jowers TP, Brinkmann MM, Holstermann B, Mack C, Dickinson P, Hohenberg H, Ghazal P, Brune W (2012). Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade. PLoS Pathog. 8/2012; PubMed

Brune W (2010). Inhibition of programmed cell death by cytomegaloviruses. Virus Res. 157/2011; PubMed